Rotor syndrome 5079793 214251281 2008-05-22T19:16:24Z Arcadian 104523 nav {{refimprove|date=December 2007}} {{Infobox_Disease | Name = {{PAGENAME}} | Image = Bilirubin.svg | Caption = [[Bilirubin]] | DiseasesDB = 11671 | ICD10 = {{ICD10|E|80|6|e|70}} | ICD9 = {{ICD9|277.4}} | ICDO = | OMIM = 237450 | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D006933 | }} '''Rotor syndrome''' is a rare, relatively benign [[autosomal recessive]] [[bilirubin]] disorder of unknown origin. ==Presentation== It has many things in common with [[Dubin-Johnson syndrome]] except that in Rotor Syndrome, the liver cells are not pigmented. The main symptom is a non-itching [[jaundice]]. There is a rise in [[bilirubin]] in the patient's [[Blood plasma|serum]], mainly of the conjugated type. It can be differentiated from Dubin-Johnson syndrome in the following ways: {| class="wikitable" | || '''Rotor syndrome''' || '''DJS''' |- | appearance of [[liver]] || normal histology and appearance || liver has black pigmentation |- | [[gallbladder]] visualization ||gallbladder can be visualized by USG || gallbladder cannot be visualized |- | total urine [[coproporphyrin]] content || high with <70% being isomer 1 || normal with >80% being isomer 1 (normal urine contains more of isomer 3 than isomer 1) |} ==Eponym== Rotor syndrome is named after the [[Filipino people|Filipino]] [[Internal medicine|internist]], [[Arturo Belleza Rotor]] (1907-1988).<ref>{{WhoNamedIt|synd|2296}}</ref> == See also == * [[Jaundice]] * [[Bilirubin metabolism]] * [[Dubin-Johnson syndrome]] * [[Gilbert syndrome]] * [[Crigler-Najjar syndrome]] ==References== {{reflist}} == External links == * {{eMedicine|med|1065}} - article on eMedicine on conjugated hyperbilirubinemia {{Heme metabolism disorders}} [[Category:Syndromes]] [[Category:Metabolic disorders]] [[Category:Genetic disorders]] [[Category:Autosomal recessive disorders]] [[Category:Inborn errors of metabolism]] [[Category:Hepatology]] {{genetic-disorder-stub}} [[de:Rotor-Syndrom]] [[es:Síndrome de Rotor]] [[it:Sindrome di Rotor]] [[pl:Zespół Rotora]]