S-Methylmethionine 533199 222857928 2008-07-01T13:26:55Z DOI bot 6652755 Citation maintenance. Added: issue. Formatted: title. You can [[WP:DOI|use this bot]] yourself! Please [[User:DOI_bot/bugs|report any bugs]]. {{Chembox new | Reference = <ref>''Merck Index'', 11th Edition, '''9942'''.</ref> | ImageFile = Methylmethionine.png | ImageSize = | IUPACName = (3-Amino-3-carboxy-propyl)-dimethyl-sulfonium | OtherNames = ''S''-Methyl-<small>L</small>-methionine<br>Vitamin U | Section1 = {{Chembox Identifiers | CASNo = 4727-40-6 | PubChem = 458 | SMILES = C[S+](C)CCC(C(=O)O)N }} | Section2 = {{Chembox Properties | Formula = C<sub>6</sub>H<sub>15</sub>NO<sub>2</sub>S | MolarMass = 164.247 g/mol | Appearance = | Density = | MeltingPtC = 139 | Melting_notes = decomposition | BoilingPt = | Solubility = }} | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | Autoignition = }} }} '''''S''-Methylmethionine''', or '''''S''-methyl-<small>L</small>-methionine''', is a derivative of [[methionine]] with [[chemical formula]] [[Carbon|C]]<sub>6</sub>[[Hydrogen|H]]<sub>15</sub>[[Nitrogen|N]][[Oxygen|O]]<sub>2</sub>[[Sulfur|S]]. In [[plant]]s, it is produced from methionine by the [[enzyme]] [[methionine S-methyltransferase]]. ''S''-Methylmethionine is sometimes called '''vitamin U''' in [[naturopathic medicine]], but it is not recognized as a [[vitamin]] by mainstream [[nutrition]] science. Methionine in itself has not been demonstrated as effective for treating [[peptic ulcer|peptic]] and [[duodenal ulcer|duodenal]] [[ulcer|'''ulcers]].<ref>{{cite journal | author = STREHLER E | title = Contribution to the knowledge of the ulcer-preventive factor (so-called vitamin U) intestinal activity of vitamin U-containing dry extracts of cabbage. II | journal = Hippokrates | volume = 29 | issue = 19 | pages = 629–633 | year = 1958 | pmid = 13610295}}</ref><ref>{{cite journal | author = Trusov VV, Oreshkov TM | title = Therapeutic effect of MMSC1 (vitamin U) on gastric and intestinal function in the treatment of patients with chronic gastritis | journal = Sovetskaia meditsina | volume = 8 | issue = 0 | pages = 121–124 | year = 1974 | pmid = 4428258}}</ref><ref>{{cite journal | author = Roediger WE, Babidge W, Millard S. | title = Methionine derivatives diminish sulphide damage to colonocytes--implications for ulcerative colitis | journal = Gut | volume = 39 | issue = 1 | pages = 77–81 | year = 1996 | pmid = 8881814 | doi = 10.1136/gut.39.1.77}}</ref> Its proponents claim that sources of methionine are limited, or claim it can be found only in raw [[cabbage]]; however, these claims are incorrect. Methionine is a common [[amino acid]] found in a wide variety of [[fruit]]s, [[vegetable]]s, and [[legume]]s. == Origins of "Vitamin U" == Garnett Cheney, M.D. demonstrated in the 1950s that fresh, raw cabbage juice could significantly increase the rate of healing in patients with [[gastrointestinal ulceration]], and his work was published in peer reviewed journals. <ref>{{cite journal | author = Cheney G | title = Rapid healing of peptic ulcers in patients receiving fresh cabbage juice | journal = California Medicine | volume = 70 | issue = 10 | year = 1949 }}</ref> <ref>{{cite journal | author = Cheney G | title = Vitamin U concentrate therapy of peptic ulcer | journal = American Journal of Gastroenterology | volume = 21 | issue = 3 | pages = 230–250 | year = 1954 | pmid = 13138563}}</ref> <ref>{{cite journal | author = Cheney G | title = The medical management of gastric ulcers with vitamin U therapy | journal = Stanford Med Bull | volume = 13 | issue = 2 | pages = 204–214 | year = 1955 | pmid = 14386172}}</ref> <ref>{{cite journal | author = Cheney G, Waxler SH, Miller IJ | title = Vitamin U therapy of peptic ulcer; experience at San Quentin Prison | journal = Calif Med| volume = 84 | issue = 1 | pages = 39–42 | year = 1956 | pmid = 13276831}}</ref> In 1952, he had 100 peptic ulcer patients drink 4 glasses of fresh, raw cabbage juice daily. This was in place of surgery or drug therapy, with otherwise no alterations in diet. Self-reports from patients indicated dramatically reduced pain, while x-rays demonstrated significantly reduced healing time. 81% of the patients were symptom-free within one week, and over two thirds were better within four days.<ref>{{cite journal | author = Cheney G | title = Vitamin U Therapy of Peptic Ulcer | journal = California Medicine | volume = 77 | issue = 4 | pages = 248–252 | year = 1952 | pmid = 13009468}}</ref> Note that the average healing time for peptic uler patients given standard hospital treatment in 1952 was over a month. Dr. Cheney went on further to treat gastric and duodenal ulcers with raw cabbage juice, with similar results.<ref>{{cite journal | author = Cheney G | title = The medical management of gastric ulcers with vitamin U therapy | journal = Stanford Med Bull | volume = 13 | issue = 2 | pages = 204–214 | year = 1955 | pmid = 14386172}}</ref> Dr. Cheney found that he could not bring on the same results when the cabbage juice was not fresh, and that heated cabbage juice was completely ineffective.<ref>{{cite journal | author = Cheney G | title = The nature of the antipepticulcer dietary factor | journal = Stanford Med Bull | volume = 8 | issue = 3 | pages = 144–161 | year = 1950 | pmid = 14782068}}</ref> <ref>{{cite journal | author = Cheney G | title = Antipeptic ulcer dietary factor |journal = American Dietetics Association | volume = 26 | issue = 9 | year = 1950 }}</ref> Hence, it was understood that an unknown, heat-sensitive substance was responsible for the results. Dr. Cheney dubbed the unidentified substance(s) responsible for the rapid healing, "Vitamin U", although this is not recognised as a vitamin, rather merely a name. == References == {{Reflist}} {{DEFAULTSORT:Methylmethionine, S-}} [[Category:Proteinogenic amino acids]] [[Category:Sulfur amino acids]] [[Category:Thioethers]] [[Category:Essential amino acids]] [[et:S-metüülmetioniin]] [[ja:ビタミンU]]