SDHC
1393693
222615079
2008-06-30T07:44:27Z
Stevefis
336881
{{otheruses}}
{{protein
| Name = succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
| caption =
| image=SuccDeh.svg
| width=250
| HGNCid = 10682
| Symbol = SDHC
| AltSymbols = PGL3
| EntrezGene = 6391
| OMIM = 602413
| RefSeq = NM_003001
| UniProt = Q99643
| PDB =
| ECnumber =
| Chromosome = 1
| Arm = q
| Band = 21
| LocusSupplementaryData =
}}
'''SDHC''' is an abbreviation for '''succinate dehydrogenase complex subunit C'''.
The term SDHC can refer to;
* The protein subunit itself.
* The gene that codes for this protein.
The [[succinate dehydrogenase]] (SDH) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). The [[SDHA]] subunit is connected to the [[SDHB]] subunit on the hydrophilic, catalytic end of the complex. Electrons removed from succinate transfer SDHA, to SDHB and further to the '''SDHC'''/[[SDHD]] subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane.
==Function of the SDHC protein==
The SDH complex is located on the inner membrane of the [[mitochondria]] and participates in both the [[Citric Acid Cycle]] and [[Respiratory chain]].
SDHC acts as an intermediate in the basic SDH enzyme action:
# [[SDHA]] converts [[succinate]] to [[fumarate]] as part of the [[Citric Acid Cycle]]. This reaction also converts [[FAD]] to [[Flavin|FADH<sub>2</sub>]].
# Electrons from the FADH<sub>2</sub> are transferred to the SDHB subunit iron clusters [2Fe-2S],[4Fe-4S],[3Fe-4S]. This function is part of the [[Respiratory chain]]
# '''Finally the electrons are transferred to the [[Ubiquinone]] (Q) pool via the SDHC/[[SDHD]] subunits'''.
==Gene that codes for SDHC==
The gene that codes for the SDHC protein is nuclear, even though the protein is located in the inner membrane of the [[mitochondria]]. The location of the gene in humans is on the [[Chromosome 1 (human)|first chromosome]] at q21. The [[gene]] is partitioned in 6 [[exon]]s.
The expressed protein has 170 amino acids.
SDHC was previously called '''PGL3'''.
{{biochem-stub}}
{{Citric acid cycle enzymes}}
[[Category:Genes]]