SDHC 1393693 222615079 2008-06-30T07:44:27Z Stevefis 336881 {{otheruses}} {{protein | Name = succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | caption = | image=SuccDeh.svg | width=250 | HGNCid = 10682 | Symbol = SDHC | AltSymbols = PGL3 | EntrezGene = 6391 | OMIM = 602413 | RefSeq = NM_003001 | UniProt = Q99643 | PDB = | ECnumber = | Chromosome = 1 | Arm = q | Band = 21 | LocusSupplementaryData = }} '''SDHC''' is an abbreviation for '''succinate dehydrogenase complex subunit C'''. The term SDHC can refer to; * The protein subunit itself. * The gene that codes for this protein. The [[succinate dehydrogenase]] (SDH) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). The [[SDHA]] subunit is connected to the [[SDHB]] subunit on the hydrophilic, catalytic end of the complex. Electrons removed from succinate transfer SDHA, to SDHB and further to the '''SDHC'''/[[SDHD]] subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. ==Function of the SDHC protein== The SDH complex is located on the inner membrane of the [[mitochondria]] and participates in both the [[Citric Acid Cycle]] and [[Respiratory chain]]. SDHC acts as an intermediate in the basic SDH enzyme action: # [[SDHA]] converts [[succinate]] to [[fumarate]] as part of the [[Citric Acid Cycle]]. This reaction also converts [[FAD]] to [[Flavin|FADH<sub>2</sub>]]. # Electrons from the FADH<sub>2</sub> are transferred to the SDHB subunit iron clusters [2Fe-2S],[4Fe-4S],[3Fe-4S]. This function is part of the [[Respiratory chain]] # '''Finally the electrons are transferred to the [[Ubiquinone]] (Q) pool via the SDHC/[[SDHD]] subunits'''. ==Gene that codes for SDHC== The gene that codes for the SDHC protein is nuclear, even though the protein is located in the inner membrane of the [[mitochondria]]. The location of the gene in humans is on the [[Chromosome 1 (human)|first chromosome]] at q21. The [[gene]] is partitioned in 6 [[exon]]s. The expressed protein has 170 amino acids. SDHC was previously called '''PGL3'''. {{biochem-stub}} {{Citric acid cycle enzymes}} [[Category:Genes]]