Salmeterol
1266901
224603853
2008-07-09T16:48:10Z
ChemNerd
2246483
Quick-adding category "Phenethylamines" (using [[WP:HOTCAT|HotCat]])
{{drugbox |
| IUPAC_name = 2-(hydroxymethyl)-4-{1-hydroxy-2-[6-(4-phenylbutoxy) hexylamino]ethyl}phenol
| image = Salmeterol.png
| CAS_number = 89365-50-4
| ATC_prefix = R03
| ATC_suffix = AC12
| PubChem = 5152
| DrugBank = APRD00277
| C = 25 | H = 37 | N = 1 | O = 4
| molecular_weight = 415.57
| bioavailability =
| protein_bound = 96%
| metabolism = [[hepatic]] [[CYP3A4]]
| elimination_half-life = 5.5 Hours
| excretion =
| pregnancy_category =
| legal_AU = S4
| legal_CA =
| legal_UK = POM
| legal_US = Rx-only
| legal_status =
| routes_of_administration = Inhalation
}}
'''Salmeterol''' is a long-acting [[beta2-adrenergic receptor agonist]] [[medication|drug]] that is currently prescribed for the treatment of [[asthma]] and chronic obstructive pulmonary disease ([[COPD]]). It is currently available as a [[metered-dose inhaler]] (MDI) or a proprietary "disk-styled" inhaler that releases a powdered form of the drug.
==Indications==
It is a [[long acting beta-adrenoceptor agonist]] (LABA), usually only prescribed for severe persistent asthma following previous treatment with a short-acting beta agonist such as [[salbutamol]] and is prescribed concurrently with a corticosteroid, such as [[beclomethasone]]. The primary noticeable difference of salmeterol to [[salbutamol]] is that the duration of action lasts approximately 12 hours in comparison with 4–6 hours of salbutamol.
When used regularly every day as prescribed, inhaled salmeterol decreases the number and severity of asthma attacks. However, like all LABA medications, it is not for use for relieving an asthma attack that has already started.
Inhaled salmeterol works like other beta 2-agonists, causing bronchodialation by relaxing the smooth muscle in the airway so as to treat the exacerbation of asthma. The long duration of formoterol action occurs by the formoterol molecules initially diffusing into the plasma membrane of the lung cells, and then slowly being released back outside the cell where they can come into contact with the beta-2 adrenoceptors. [[Formoterol]] has been demonstrated to have a faster onset of action than salmeterol as a result of a lower [[lipophilic|lipophilicity]], and has also been demonstrated to be more potent—a 12 µg dose of formoterol has been demonstrated to be equivalent to a 50 µg dose of salmeterol.
==Formulations==
Currently available long-acting [[beta2-adrenergic receptor agonist|beta<sub>2</sub>-adrenoceptor agonists]] include salmeterol, [[formoterol]], [[bambuterol]], and sustained-release oral [[albuterol]]. Combinations of inhaled steroids and long-acting bronchodilators are becoming more widespread; the most common combination currently in use is [[fluticasone/salmeterol]] ('''Advair''' in the United States, '''Seretide''' in the UK).
==History and concerns==
[[Image:AsthmaInhaler.jpg|thumb|180px|A typical [[inhaler]], of [[salmeterol|Serevent (salmeterol)]]]]
Salmeterol, marketed and manufactured by [[GlaxoSmithKline]], in the 1980s and was released as Serevent in 1990. However, the product is under license from Allen & Hanburys.(UK)
In November of 2005, the American [[Food and Drug Administration|FDA]] released a health advisory[http://www.fda.gov/cder/drug/infopage/LABA/default.htm], alerting the public to findings that show the use of Long-acting β<sub>2</sub>-agonists could lead to a worsening of symptoms, and in some cases death.
Whilst the use of inhaled LABAs are still recommended in asthma guidelines for the resulting improved symptom control,<!--
--><ref name=SIGN>British Thoracic Society & Scottish Intercollegiate Guidelines Network (SIGN). ''British Guideline on the Management of Asthma''. Guideline No. 63. Edinburgh:SIGN; 2004. ([http://www.sign.ac.uk/guidelines/fulltext/63/index.html HTML], [http://www.sign.ac.uk/pdf/sign63.pdf Full PDF], [http://www.sign.ac.uk/pdf/qrg63.pdf Summary PDF])</ref>
further concerns have been raised, by a large meta-analysis of the pooled results from 19 trials with 33,826 participants, that salmeterol may increase the small risks of asthma deaths and this additional risk is not reduced with the additional use of inhaled steroids (e.g. as with the combination product [[Fluticasone/salmeterol]]).<!--
--><ref>{{cite journal | author = Salpeter S, Buckley N, Ormiston T, Salpeter E | title = [http://www.healthsentinel.com/org_news.php?event=org_news_print_list_item&id=116 Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths] | journal = Ann Intern Med | volume = 144 | issue = 12 | pages = 904–12 | year = 2006 | pmid = 16754916}}</ref>
This seems to occur because although LABAs relieve asthma symptoms, they also promote bronchial inflammation and sensitivity without warning.<!--
--><ref>{{cite news | author=Krishna Ramanujan | title=[http://www.news.cornell.edu/stories/June06/AsthmaDeaths.kr.html Common asthma inhalers cause up to 80 percent of asthma-related deaths, Cornell and Stanford researchers assert] | month=June 9 | year=2006 | publisher=ChronicalOnline - Cornell University}}</ref>
==See also==
* [[Asthma]]
* [[Beta2-adrenergic receptor agonist]]
==Footnotes==
<references/>
{{Asthma_and_copd_rx}}
[[Category:Beta-adrenergic agonists]]
[[Category:Asthma]]
[[Category:Phenethylamines]]
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