Selenomethionine
1554372
206958760
2008-04-20T20:57:13Z
Abelani
1842
Added source info about MSE as a selenium supplement
{{Chembox new
| ImageFile = Selenomethionine.jpg
| ImageSize = 130px
|ImageName = Selenomethionine: chemical structure
| IUPACName = 2-amino-4-methylselanyl-butanoic acid
| OtherNames = MSE
| Section1 = {{Chembox Identifiers
| CASNo = 3211-76-5
| PubChem =
| SMILES =
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| Section2 = {{Chembox Properties
| Formula = C<sub>5</sub>H<sub>11</sub>NO<sub>2</sub>Se
| MolarMass = 196.106 g/mol
| Appearance =
| Density =
| MeltingPt =
| BoilingPt =
| Solubility =
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| Section3 = {{Chembox Hazards
| MainHazards =
| FlashPt =
| Autoignition =
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'''Selenomethionine''' is an [[amino acid]] containing [[selenium]]. The [[L-isomer]] of selenomethionine, known as Se-met and Sem, is a common natural food source of [[selenium]]. In vivo, selenomethionine is randomly incorporated instead of methionine and is readily oxidized. It’s antioxidant activity arises from its ability to deplete reactive species. Selenium and sulfur are [[chalcogen]] elements that share many chemical properties and the substitution of methionine to selenomethionine has no effect on proteins structure and function.
Incorporation of selenomethionine into proteins in place of [[Methionine]] aids the structure elucidation of proteins by [[X-ray crystallography]] using [[multi-wavelength anomalous diffraction]] (MAD). The incorporation of heavy atoms such as Selenium helps solving the phase problem in X-ray crystallography.
It has been suggested that selenomethionine, which is an organic form of selenium, is easier for the human body to absorb than [[selenite]], which is an inorganic form.<ref name="CL_CancerPrevention">{{cite web |url= http://www.consumerlab.com/reviews/Supplements_for_Cancer_Prevention_Green_Tea_Lycopene_and_Selenium/cancerprevention/ |title= Product Review: Supplements for Cancer Prevention (Green Tea, Lycopene, and Selenium) |publisher= [[ConsumerLab.com]] |accessdate=2008-04-20 |quote= <small>Selenium supplements are available in organic and inorganic forms. Some research suggests that the inorganic form, selenite, is harder for the body to absorb than organic forms such as selenomethionine (selenium bound to methionine, an essential amino acid) or high-selenium yeast (which contains selenomethionine). A recent clinical trial found that selenomethionine had 19% better absorption than selenite; absorption from selenium yeast was about 10% better than selenite.</small>}}</ref> It was determined in a clinical trial that selenomethionine is absorbed 19% better than selenite.<ref name="CL_CancerPrevention"/>
==References==
{{reflist}}
==External links==
* [http://xray.bmc.uu.se/hicup/MSE/ PDB file for MSE]
* [http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=n/a&template=het2pdb.html¶m1=MSE PDB entries containing Het Group MSE]
[[Category:Amino acids]]
[[Category:Selenium compounds]]
[[de:Selenomethionin]]