Serotype 1936485 221892765 2008-06-26T15:42:34Z 67.207.134.95 [[WP:UNDO|Undid]] revision 220733801 by [[Special:Contributions/Kengzy|Kengzy]] ([[User talk:Kengzy|talk]]) [[Image:anti-HLA agglutinated RBC.PNG|frame|right|'''Agglutination of [[HLA-A3]] positive [[red blood cell]]s''' (RBCs) with anti-A3 alloreactive [[antisera]] containing Anti-A3 [[IgM]]]] ''For the term's use in bacteriology, see [[serovar]].'' {{Merge|serovar|date=March 2008}} {{Cleanup|date=December 2007}} ==Serotype (Allograft)== Transplants between genetically non-identical humans induce the creation of antibodies in the recipient. These non-identical [[cell-surface receptor]]s between the donor and recipient produce antiserum reactive to the donor proteins. Under selection conditions one or two [[isoform]] specificities are obtained. This results in a serotype that is capable of identifying other individuals who have those proteins. This serotyping along with new-PCR based techniques are how tissues for organ-donor programs are characterized. (for more detailed information see [[Human leukocyte antigens]] and [[HLA-A#Historical_Guide_to_Understanding_Nomenclature|HLA Serotype tutorial]].) ==Human leukocyte antigens== {| class="wikitable" align="left" |+Serotypes according the HLA (MHC) locus |- ! HLA || # of || Broad || Split |- ! Locus || Serotypes || Antigens || Antigens |-align = "center" | '''[[HLA-A|A]]''' || 25 || 4 || 15 |-align = "center" | '''[[HLA-B|B]]''' || 50 || 9 || 24 |-align = "center" | '''[[HLA-C|C]]'''* || 12 || 1 || 2 |-align = "center" |'''[[HLA-DR|DR]]''' || 21 || 4 || 8 |-align = "center" | '''[[HLA-DQ|DQ]]''' || 8 || 2 || 5 |-align = "center" | '''[[HLA-DP|DP]]'''* || || || |- |colspan = "4" |*DP and many Cw require SSP-PCR for typing. |} <br clear="all"/> ==External links== * [http://tech.groups.yahoo.com/group/DNAanthro/ Molecular Anthropology Yahoo Group]<br /> * [http://www.allelefrequencies.net HLA Allele and Haplotype Frequency Database] {{Surface antigens}} [[Category:Serology]] [[es:Serotipo]]