Serotype
1936485
221892765
2008-06-26T15:42:34Z
67.207.134.95
[[WP:UNDO|Undid]] revision 220733801 by [[Special:Contributions/Kengzy|Kengzy]] ([[User talk:Kengzy|talk]])
[[Image:anti-HLA agglutinated RBC.PNG|frame|right|'''Agglutination of [[HLA-A3]] positive [[red blood cell]]s''' (RBCs) with anti-A3 alloreactive [[antisera]] containing Anti-A3 [[IgM]]]]
''For the term's use in bacteriology, see [[serovar]].''
{{Merge|serovar|date=March 2008}}
{{Cleanup|date=December 2007}}
==Serotype (Allograft)==
Transplants between genetically non-identical humans induce the creation of antibodies in the recipient. These non-identical [[cell-surface receptor]]s between the donor and recipient produce antiserum reactive to the donor proteins. Under selection conditions one or two [[isoform]] specificities are obtained. This results in a serotype that is capable of identifying other individuals who have those proteins. This serotyping along with new-PCR based techniques are how tissues for organ-donor programs are characterized. (for more detailed information see [[Human leukocyte antigens]] and [[HLA-A#Historical_Guide_to_Understanding_Nomenclature|HLA Serotype tutorial]].)
==Human leukocyte antigens==
{| class="wikitable" align="left"
|+Serotypes according the HLA (MHC) locus
|-
! HLA || # of || Broad || Split
|-
! Locus || Serotypes || Antigens || Antigens
|-align = "center"
| '''[[HLA-A|A]]''' || 25 || 4 || 15
|-align = "center"
| '''[[HLA-B|B]]''' || 50 || 9 || 24
|-align = "center"
| '''[[HLA-C|C]]'''* || 12 || 1 || 2
|-align = "center"
|'''[[HLA-DR|DR]]''' || 21 || 4 || 8
|-align = "center"
| '''[[HLA-DQ|DQ]]''' || 8 || 2 || 5
|-align = "center"
| '''[[HLA-DP|DP]]'''* || || ||
|-
|colspan = "4" |*DP and many Cw require SSP-PCR for typing.
|}
<br clear="all"/>
==External links==
* [http://tech.groups.yahoo.com/group/DNAanthro/ Molecular Anthropology Yahoo Group]<br />
* [http://www.allelefrequencies.net HLA Allele and Haplotype Frequency Database]
{{Surface antigens}}
[[Category:Serology]]
[[es:Serotipo]]