Shy-Drager syndrome 317316 220555983 2008-06-20T12:44:44Z DOI bot 6652755 Citation maintenance. You can [[WP:DOI|use this bot]] yourself! Please [[User:DOI_bot/bugs|report any bugs]]. {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 12042 | ICD10 = {{ICD10|G|90|3|g|90}} | ICD9 = {{ICD9|333.0}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D012791 | }} '''Shy-Drager syndrome''' is a rare, progressively [[degenerative disease]] of the [[autonomic nervous system]]. It is named after Dr Milton Shy and Dr Glenn Drager, who identified this syndrome in [[1960]].<ref>{{WhoNamedIt|synd|875}}</ref><ref>{{cite journal |author=Shy GM, Drager GA |title=A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study |journal=Arch. Neurol. |volume=2 |issue= |pages=511–27 |year=1960 |pmid=14446364 |doi=}}</ref> The American Autonomic Society and the American Academy of Neurology deprecated it as a disease entity in [[1996]],<ref>{{cite journal |author= | title=Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy |journal=Neurology |volume=46 |issue=5 |pages=1470 |year=1996 |pmid=8628505 |doi=}}</ref> and existing cases were redefined as [[multiple system atrophy]] with autonomic phenomena. The name "Shy-Drager syndrome" is still used occasionally for [[multiple system atrophy]] when the primary symptoms are autonomic failure. ==Symptoms== *Problems with the autonomic nervous system, such as [[dysphagia]], [[incontinence]], [[hypotension]], [[gastroparesis]], and [[erectile dysfunction]], among others (see [[autonomic neuropathy]]). *[[Parkinsonian]] symptoms *Other nonspecific neurologic symptoms such as [[ataxia]] and [[corticospinal tract|pyramidal]] symptoms{{Fact|date=December 2007}} ==Treatment== No definitive treatment currently exists. Medications used for [[Parkinson's disease]] have not shown to be useful. Treatments are generally geared to give symptomatic control, especially to maintain adequate blood pressure ([[adrenergic agonists]], and [[mineralocorticoid]] analogs such as [[fludrocortisone]]).{{Fact|date=December 2007}} ==Notable sufferers== * [[Johnny Cash]] (possible [[misdiagnosis]] of [[autonomic neuropathy]]) {{Fact|date=January 2008}} ==References== <references/> {{PNS diseases of the nervous system}} [[Category:Neurological disorders]] [[da:Shy-Drager-syndrom]] [[de:Shy-Drager-Syndrom]] [[fi:Shy-Dragerin oireyhtymä]]