Shy-Drager syndrome
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2008-06-20T12:44:44Z
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{{Infobox_Disease |
Name = {{PAGENAME}} |
Image = |
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DiseasesDB = 12042 |
ICD10 = {{ICD10|G|90|3|g|90}} |
ICD9 = {{ICD9|333.0}} |
ICDO = |
OMIM = |
MedlinePlus = |
eMedicineSubj = |
eMedicineTopic = |
MeshID = D012791 |
}}
'''Shy-Drager syndrome''' is a rare, progressively [[degenerative disease]] of the [[autonomic nervous system]]. It is named after Dr Milton Shy and Dr Glenn Drager, who identified this syndrome in [[1960]].<ref>{{WhoNamedIt|synd|875}}</ref><ref>{{cite journal |author=Shy GM, Drager GA |title=A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study |journal=Arch. Neurol. |volume=2 |issue= |pages=511–27 |year=1960 |pmid=14446364 |doi=}}</ref>
The American Autonomic Society and the American Academy of Neurology deprecated it as a disease entity in [[1996]],<ref>{{cite journal |author= | title=Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy |journal=Neurology |volume=46 |issue=5 |pages=1470 |year=1996 |pmid=8628505 |doi=}}</ref> and existing cases were redefined as [[multiple system atrophy]] with autonomic phenomena. The name "Shy-Drager syndrome" is still used occasionally for [[multiple system atrophy]] when the primary symptoms are autonomic failure.
==Symptoms==
*Problems with the autonomic nervous system, such as [[dysphagia]], [[incontinence]], [[hypotension]], [[gastroparesis]], and [[erectile dysfunction]], among others (see [[autonomic neuropathy]]).
*[[Parkinsonian]] symptoms
*Other nonspecific neurologic symptoms such as [[ataxia]] and [[corticospinal tract|pyramidal]] symptoms{{Fact|date=December 2007}}
==Treatment==
No definitive treatment currently exists. Medications used for [[Parkinson's disease]] have not shown to be useful. Treatments are generally geared to give symptomatic control, especially to maintain adequate blood pressure ([[adrenergic agonists]], and [[mineralocorticoid]] analogs such as [[fludrocortisone]]).{{Fact|date=December 2007}}
==Notable sufferers==
* [[Johnny Cash]] (possible [[misdiagnosis]] of [[autonomic neuropathy]]) {{Fact|date=January 2008}}
==References==
<references/>
{{PNS diseases of the nervous system}}
[[Category:Neurological disorders]]
[[da:Shy-Drager-syndrom]]
[[de:Shy-Drager-Syndrom]]
[[fi:Shy-Dragerin oireyhtymä]]