Succinyl-CoA 782471 210654135 2008-05-06T20:53:27Z Rockfang 5403270 changing stub name per [[Wikipedia:Stub_types_for_deletion/Log/2008/March/19|SfD]] using [[Project:AutoWikiBrowser|AWB]] {{Chembox new | ImageFile = Succinyl-CoA.png | ImageSize = 150px | IUPACName = | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 604-98-8 | PubChem = 1111 | SMILES = | MeSHName = succinyl-coenzyme+A }} | Section2 = {{Chembox Properties | Formula = C<sub>25</sub>H<sub>40</sub>N<sub>7</sub>O<sub>19</sub>P<sub>3</sub>S | MolarMass = 867.608 | Appearance = | Density = | MeltingPt = | BoilingPt = }} | Section3 = {{Chembox Hazards | Solubility = | MainHazards = | FlashPt = | Autoignition = }} }} '''Succinyl-Coenzyme A''', generally abbreviated as '''Succinyl-CoA''' or '''SucCoA''' is a combination of [[succinic acid]] and [[coenzyme A]]. ==Source== It is an important intermediate in the [[citric acid cycle]], where it is synthesized from [[Ketoglutaric acid|&alpha;-Ketoglutarate]] by [[Alpha-ketoglutarate dehydrogenase|&alpha;-ketoglutarate dehydrogenase]] through [[decarboxylation]]. During the process, [[coenzyme A]] is added. It is also synthesized from [[propionyl coenzymeA|propionyl CoA]], the odd numbered fatty acid which cannot undergo beta-oxidation. Propionyl-CoA is carboxylated to D-methylmalonyl-CoA, isomerized to L-methylmalonyl-CoA, and rearranged to yield succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an intermediate of the citric acid cycle and can be readily incorporated there. ==Fate== It is converted into [[succinate]] through the [[hydrolysis|hydrolytic]] release of coenzyme A by [[succinyl coenzyme A synthetase|succinyl-CoA synthetase]] (succinate thiokinase). Another fate of succinyl-CoA is [[porphyrin|porphyrin synthesis]], where succinyl-CoA and [[glycine]] are combined by [[aminolevulinic acid synthase|ALA synthase]] to form [[D-Aminolevulinic acid|&delta;-aminolevulinic acid]] (dALA). ==Formation== Succinyl CoA can be formed from methylmalonyl CoA through the utilization of deoxyadenosyl-B12 (deoxyadenosylcobalamin) by methylmalonyl CoA Mutase. This reaction, which requires [[vitamin B12]] to occur, is important in the catabolism of some branched-chain amino acids as well as odd-chain fatty acids. ==See also== {{citric acid cycle}} {{metabolism-stub}} [[Category:Coenzymes]] [[de:Succinyl-CoA]] [[it:Succinil-coenzima A]] [[hu:Szukcinil-koenzim A]] [[sv:Succinyl-CoA]]