Succinyl-CoA
782471
210654135
2008-05-06T20:53:27Z
Rockfang
5403270
changing stub name per [[Wikipedia:Stub_types_for_deletion/Log/2008/March/19|SfD]] using [[Project:AutoWikiBrowser|AWB]]
{{Chembox new
| ImageFile = Succinyl-CoA.png
| ImageSize = 150px
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| Section1 = {{Chembox Identifiers
| CASNo = 604-98-8
| PubChem = 1111
| SMILES =
| MeSHName = succinyl-coenzyme+A
}}
| Section2 = {{Chembox Properties
| Formula = C<sub>25</sub>H<sub>40</sub>N<sub>7</sub>O<sub>19</sub>P<sub>3</sub>S
| MolarMass = 867.608
| Appearance =
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| Section3 = {{Chembox Hazards
| Solubility =
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'''Succinyl-Coenzyme A''', generally abbreviated as '''Succinyl-CoA''' or '''SucCoA''' is a combination of [[succinic acid]] and [[coenzyme A]].
==Source==
It is an important intermediate in the [[citric acid cycle]], where it is synthesized from [[Ketoglutaric acid|α-Ketoglutarate]] by [[Alpha-ketoglutarate dehydrogenase|α-ketoglutarate dehydrogenase]] through [[decarboxylation]]. During the process, [[coenzyme A]] is added.
It is also synthesized from [[propionyl coenzymeA|propionyl CoA]], the odd numbered fatty acid which cannot undergo beta-oxidation. Propionyl-CoA is carboxylated to D-methylmalonyl-CoA, isomerized to L-methylmalonyl-CoA, and rearranged to yield succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an intermediate of the citric acid cycle and can be readily incorporated there.
==Fate==
It is converted into [[succinate]] through the [[hydrolysis|hydrolytic]] release of coenzyme A by [[succinyl coenzyme A synthetase|succinyl-CoA synthetase]] (succinate thiokinase).
Another fate of succinyl-CoA is [[porphyrin|porphyrin synthesis]], where succinyl-CoA and [[glycine]] are combined by [[aminolevulinic acid synthase|ALA synthase]] to form [[D-Aminolevulinic acid|δ-aminolevulinic acid]] (dALA).
==Formation==
Succinyl CoA can be formed from methylmalonyl CoA through the utilization of deoxyadenosyl-B12 (deoxyadenosylcobalamin) by methylmalonyl CoA Mutase. This reaction, which requires [[vitamin B12]] to occur, is important in the catabolism of some branched-chain amino acids as well as odd-chain fatty acids.
==See also==
{{citric acid cycle}}
{{metabolism-stub}}
[[Category:Coenzymes]]
[[de:Succinyl-CoA]]
[[it:Succinil-coenzima A]]
[[hu:Szukcinil-koenzim A]]
[[sv:Succinyl-CoA]]