Tetracaine
3750373
217886866
2008-06-08T04:08:53Z
58.161.43.42
{{drugbox
| IUPAC_name = 2-(dimethylamino)ethyl 4-(butylamino)benzoate
| image = Tetracaine.svg
| CAS_number = 94-24-6
| CAS_supplemental = {{CAS|136-47-0}} ([[hydrochloride]])
| ATC_prefix = C05
| ATC_suffix = AD02
| ATC_supplemental = {{ATC|D04|AB06}} {{ATC|N01|BA03}} {{ATC|S01|HA03}}
| PubChem = 5411
| DrugBank =
| C = 15 | H = 24 | N = 2 | O = 2
| molecular_weight = 264.363 g/mol
| bioavailability =
| protein_bound = 75.6
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category=
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration = Topical, Epidural, Spinal
}}
'''Tetracaine''' ([[International Nonproprietary Name|INN]], also known as '''amethocaine'''; trade name '''Pontocaine''') is a potent [[local anesthetic]] of the [[ester]] group. It is mainly used [[topical anesthetic|topically]], in [[ophthalmology]] and as an [[antipruritic]], and has been used in [[spinal anesthesia]].
In [[biomedical research]], tetracaine is used to alter the function of calcium release channels ([[ryanodine receptor]]) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely<ref>Györke, S., V. Lukyanenko, et al. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes. J Physiol 1997;500(Pt 2):297-309.</ref>.
{{pharmacology-stub}}
==References==
1. Györke, S., V. Lukyanenko, et al. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes. J Physiol 1997;500(Pt 2):297-309.
{{Vasoprotectives}}
{{Antipruritics}}
{{Local anesthetics}}
[[Category:Local anesthetics]]
[[Category:Benzoates]]
Faisal Al-Otaibi
[[fr:Tétracaïne]]
[[hu:Tetrakain]]
[[ja:テトラカイン]]