Thioxanthene
5643034
220205260
2008-06-18T19:33:43Z
169.132.18.249
I added information about the thioxanthenes.
[[Image:Thioxanthene.png|thumb|Thioxanthene]]
[[Image:Flupenthixol.png|thumb|[[Flupenthixol]]]]
'''Thioxanthene''' is a molecule in which the [[oxygen]] atom in [[xanthene]] is replaced with a [[sulfur]] atom. Various thioxanthene derivatives are used in the treatment of schizophrenia and psychosis. The activity of these compounds is related to their ability to inhibition transmission at D2 receptors, in the brain.
Thioxanthene derivatives include:
* [[Chlorprothixene]]
* [[Flupenthixol]]
* [[Thiothixene]]
* [[Zuclopenthixol]]
The [[thioxanthene]] class of neuroleptic antipsychotic psychotropics is closely related to the [[phenothiazines]], with the nitrogen at position 10 in the phenothiazines, (opposite the sulfur atom in the middle ring), replaced by a carbon atom with a double bond to the side chain. <ref>"Goodman and Gilman" </ref>
==External links==
* {{MeshName|Thioxanthenes}}
* {{GPnotebook|101056527}}
* [http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202564.html MedlinePlus]
{{heterocyclic-stub}}
[[Category:Polycyclic aromatic compounds]]
[[Category:Sulfur heterocycles]]