Tiletamine
3038195
220511170
2008-06-20T05:50:59Z
Meodipt
1170531
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[[Image:{{{image|Tiletamine.png}}}|{{{width|200}}}px|Tiletamine chemical structure]]<br /> [[Image:Tiletamine-3d-sticks.png|200px]]
''Tiletamine''
|-
| align="center" colspan="2" |2-ethylamino-2-(2-thienyl) cyclohexanone <br />''[[IUPAC nomenclature|IUPAC name]]''
|- align="center" style="border-bottom: 3px solid gray"
| '''[[CAS number]]''' <br/>
| '''[[ATC code]]''' <br />
|- align="center" style="border-bottom: 3px solid gray"
| '''[[PubChem]]''' <br />
| '''[[DrugBank]]''' <br />
|-
| bgcolor="#eeeeee" | [[smiles]]
| bgcolor="#ddeeff" | Cl.CCNC1(CCCCC1=O)c1cccs1
|-
| bgcolor="#eeeeee" | [[Chemical formula]]
| bgcolor="#ddeeff" | C<sub>12</sub>H<sub>17</sub>NOS
|-
| bgcolor="#eeeeee" | [[Molecular weight]]
| bgcolor="#ddeeff" | 223.34
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| bgcolor="#eeeeee" | [[Bioavailability]]
| bgcolor="#ddeeff" | ?
|-
| bgcolor="#eeeeee" | [[Metabolism]]
| bgcolor="#ddeeff" | Liver
|-
| bgcolor="#eeeeee" | [[Elimination half-life]]
| bgcolor="#ddeeff" | ?
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| bgcolor="#eeeeee" | [[Excretion]]
| bgcolor="#ddeeff" | kidneys
|-
| bgcolor="#eeeeee" | [[Pregnancy category (pharmaceutical)|Pregnancy category]]
| bgcolor="#ddeeff" | ?
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| bgcolor="#eeeeee" | [[Regulation of therapeutic goods|Legal status]]
| bgcolor="#ddeeff" | [[Schedule III]] (US, in comb. with zolazepam)
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| bgcolor="#eeeeee" | Routes of administration
| bgcolor="#ddeeff" | [[intravenous]], [[intramuscular]] (approved in the US for dogs and cats), subcutaneous
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'''Tiletamine''' is a [[dissociative anesthetic]] and [[pharmacology|pharmacologically]] classified as an [[NMDA receptor antagonist]]. It is related chemically and pharmacologically to other anesthetics in this family such as [[ketamine]] and [[phencyclidine]]. Tiletamine hydrochloride exists as odourless white crystals.
It is used in [[veterinary medicine]] in the compound product ''Telazol'' (tiletamine/[[zolazepam]], 50mg/ml of each in 5ml vial) as an injectable anesthetic. It is sometimes used in combination with [[xylazine]] (''Rompun'') to tranquilize large [[mammal]]s such as [[bear]]s and [[horse]]s. Telazol is the only commercially available tiletamine product in the USA.
CONTRAINDICATED in patients of an ASA statues of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.
Tiletamine/zolazepam products are classified as [[Schedule III]] [[controlled substance]]s in the [[United States]].
{{Dissociative_hallucinogens}}
{{Glutamate_receptor_ligands}}
[[Category:Anesthetics]]
[[Category:NMDA receptor antagonists]]
[[Category:Dissociatives]]
[[Category:Thiophenes]]
{{pharma-stub}}