Tolfenamic acid
5691841
208194812
2008-04-25T21:10:00Z
Chowbok
54304
clean up, Replaced: 1443 - 1447 → 1443–1447 (3) using [[Project:AutoWikiBrowser|AWB]]
{{Drugbox|
|IUPAC_name = 2-[(3-chloro-2-methylphenyl)amino]benzoic acid)."<ref>Kim Vilbour Andersen, Sine Larsen, Børge Alhede, Niels Gelting and Ole Buchardt [http://www.rsc.org/Publishing/Journals/P2/article.asp?doi=P29890001443 Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities] J. Chem. Soc., Perkin Trans. 2, 1989, 1443 - 1447, DOI:10.1039/P29890001443</ref>
| image=Tolfenamic_Acid.png
| width= 220
| CAS_number= 13710-19-5
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| ATC_supplemental=
| PubChem= 5507
| DrugBank=
| C=14 | H=12 | Cl=1 | N=1 | O=2
| molecular_weight = 261.707
| bioavailability=
| metabolism =
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| routes_of_administration= oral
}}
'''Tolfenamic acid''' (TA) is one of the class of [[Non-steroidal anti-inflammatory drug|non steroidal anti-inflammatory drugs]] ([[NSAID]]s). It is used to treat the symptoms of migraine.
== Other possible uses ==
*A study concludes, "TA was found significantly better than placebo in the subjective evaluation of drug efficacy (p<0.001) and in reducing the reported hangover symptoms in general (p < 0.01). In the TA group, significantly lower symptom scores were obtained for headache (p<0.01), and for nausea, vomiting, irritation, tremor, thirst and dryness of mouth (all p < 0.05)."<ref>S. Kaivola1, J. Parantainen, T. Österman and H. Timonen [http://www.blackwell-synergy.com/links/doi/10.1046%2Fj.1468-2982.1983.0301031.x Hangover headache and prostaglandins: Prophylactic treatment with tolfenamic acid] ''Cephalalgia'' Volume 3 Page 31 - March 1983 doi:10.1046/j.1468-2982.1983.0301031.x</ref>
== Commercial names ==
Commercial names for tolfenamic acid include:
*[http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?DocumentID=449 Clotam Rapid]
== External links ==
*[http://www.diseasesdatabase.com/ddb31603.htm Tolfenamic acid information]
== References ==
<references/>
{{NSAIDs}}
{{Anti-inflammatory and antirheumatic products}}
[[Category:Non-steroidal anti-inflammatory drugs]]
[[Category:Antipyretics]]
[[Category:Analgesics]]
[[Category:Benzoic acids]]
{{pharma-stub}}
[[de:Tolfenaminsäure]]