Tophus 1150594 162571959 2007-10-06T00:42:43Z Countincr 3801074 clean up using [[Project:AutoWikiBrowser|AWB]] [[Image:GoutTophiElbow.JPG|right|thumb|200px|Tophus on the elbow of a middle aged man with chronic gout.]] A '''tophus''' (Latin: "stone", plural '''tophi''') is a deposit of [[crystal]]lised [[uric acid|monosodium urate]] in people with longstanding [[hyperuricemia]]. At this stage, most have already developed symptoms of the associated crystal arthopathy known as [[gout]]. Tophi form in the [[joints]], [[cartilage]], [[bone]]s, and other places throughout the body. Sometimes, tophi break through the [[skin]] and appear as white or yellowish-white, chalky [[nodules]]. Without treatment, tophi may develop on average about ten years after the onset of the [[disease]], although their first appearance can range from three to forty-two years. They are more apt to appear early in the course of the disease in people who are older in age. In the elderly population, women appear to be at higher risk for tophi than men. [[Category:Rheumatology]] [[Category:Gross pathology]] {{pathology-stub}}