Trenbolone
2943479
225299707
2008-07-12T23:34:53Z
Iridescent
937705
Reverted edits by [[Special:Contributions/70.107.195.172|70.107.195.172]] (using [[WP:HG|Huggle]])
{{Drugbox|
|IUPAC_name = 17β-Hydroxyestra-4,9,11-trien-3-one
| image=Trenbolone.png
| CAS_number=10161-33-8
| ATC_prefix=
| ATC_suffix=
| ATC_supplemental=
| PubChem=25015
| DrugBank=
| C=18 | H=22 | O=2
| molecular_weight = 270.37
| bioavailability= 100% (intramuscular)
| metabolism = 5 months
| elimination_half-life= 3 days
| excretion = [[Urine|Urinary]]:%
| pregnancy_category = X
| legal_status = Illegal ([[United States|US]])<br>[[Controlled Drugs and Substances Act|Schedule IV]] ([[Canada|CA]])
| routes_of_administration= [[Intramuscular injection|Intramuscular]]
}}
'''Trenbolone''' is a [[steroid]] used by [[veterinarian]]s on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is not used in an unrefined form, but is rather administered as trenbolone acetate ('''Finaplix Gold''' from Valopharm USA, '''TREMBLONA QV75''' from Quality Vet, Mexico), Trenbolone enanthate or Trenbolone cyclohexylmethylcarbonate ([[Parabolan]] from Laboratoires NEGMA until 1997). Plasma lipases then remove the ester in the bloodstream leaving free trenbolone.
==Illicit Use==
No trenbolone compounds have been approved by the [[Food and Drug Administration|FDA]] for human use,<ref>[http://www.mesomorphosis.com/articles/collins/anabolic-steroids-and-the-law.htm Anabolic Steroids and the Athlete: The Legal Issues by Rick Collins, Esq<!-- Bot generated title -->]</ref> due to a lack of clinical applications and some potential negative side-effects.<ref>[http://www.mesomorphosis.com/steroid-profiles/trenbolone.htm Trenbolone Acetate (Finaplix) Profile<!-- Bot generated title -->]</ref> It is classified as a [[Controlled Substances Act#Schedule III drugs|Schedule III drug]] under the [[Controlled Substances Act]]. However, [[bodybuilding|bodybuilders]] have been known to use the drug illicitly in order to increase body mass more effectively than by [[weight training]] alone. A normal bodybuilding dosage can range from 200 mg/week up to 1400 mg/week. Due to the relatively short metabolic half-life of trenbolone acetate, dosages should commonly be split into injections at least once every two days. Trenbolone enanthate can be injected once a week.
Trenbolone acetate is often referred to as "Fina" by illicit users, because injectible trenbolone acetate is often prepared from Finaplix H pellets, an ear-implant used by cattle ranchers to maintain the weight of cattle during shipping to slaughter.
Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of [[testosterone]].<ref>[http://www.aensi.org/aeb/2007/39-43.pdf Tanveer Beg, Yasir Hasan Siddique and Mohammad Afzal. Chromosomal Damage Induced by Androgenic Anabolic Steroids, Stanozolol and Trenbolone, in Human Lymphocytes. Advances in Environmental Biology, 1(1): 39-43, 2007]</ref> Once metabolised, the drugs have the effect of increasing [[nitrogen]] uptake by muscles, leading to an increase in the rate of [[protein synthesis]]. It also has the secondary effects of stimulating appetite, reducing the amount of [[lipid|fat]] being deposited in the body, and decreasing the rate of [[anabolism|catabolism]]. Trenbolone has proven popular with anabolic steroid users as it is not metabolised by [[aromatase]] or [[5-alpha reductase|5α-reductase]] into [[estrogen]]ic compounds such as [[estradiol]], or into [[dihydrotestosterone|DHT]]. This means that it also does not cause any water retention normally associated with highly androgenic steroidal compounds like [[testosterone]] or [[methandrostenolone]]. It is also loved by many for the dramatic strength increases commonly experienced with it.
Short-term side effects include [[insomnia]], [[high blood pressure]], increased aggression, night sweats, and increased [[libido]]. However, since women will suffer [[virilization]] effects even at small doses, this drug should not be taken by a female. Urban wisdom/myth in bodybuilding culture, states that the use of the drug over extended periods of time can lead to [[kidney]] damage. The kidney toxicity has not yet been proven, and scientific evidence supporting the idea is suspiciously absent from the bodybuilding community that perpetuates this idea. The origin of this myth most likely has to do with the rust colored oxidized metabolites of trenbolone which are excreted in urine and often mistaken for blood. After Schänzer (Clin Chem 1996; 42(7): 1001-1020, Metabolism of anabolic androgenic steroids) trenbolone and 17epi-trenbolone are both excreted (in urine) as conjugates that can be hydrolyzed with beta-glucuronidase. This implies that trenbolone leaves the body as beta-glucuronides or sulfates, which means mostly non metabolized.
[[Image:Finaplix_gold.jpg|thumb|Finaplix Gold, Manufactured by Valopharm]]
==References==
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[[Category:Anabolic steroids]]
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[[it:Trenbolone]]
==External links==
[http://www.revalor.com/finaplix.asp Intervet]
{{Anabolic steroids}}
[[Category:Anabolic steroids]]