Triamterene 2164556 214153316 2008-05-22T09:39:29Z Thijs!bot 1392310 robot Adding: [[es:Triamtereno]] {{drugbox | IUPAC_name = 6-phenylpteridine-2,4,7-triamine | image = Triamterene.svg | CAS_number = 396-01-0 | ATC_prefix = C03 | ATC_suffix = DB02 | ATC_supplemental = | PubChem = 5546 | DrugBank = APRD00079 | C = 12 | H = 11 | N = 7 | molecular_weight = 253.263 g/mol | bioavailability = | protein_bound = 97% | metabolism = | elimination_half-life = | pregnancy_category = | legal_status = | routes_of_administration = }} '''Triamterene''' (trade name '''Dyrenium''') is a [[potassium-sparing diuretic]] used in combination with [[thiazide]] diuretics for the treatment of [[hypertension]] and [[edema]]. This medication is best avoided in patients with chronic kidney disease due to the possibility of [[hyperkalemia]]. People using this drug should use [[salt substitute]] very cautiously.<ref>LoSalt [http://www.losalt.com/docs/lo_salt_web_advice.pdf Advisory Statement] (PDF)</ref> ==Mode of action== Triamterene directly blocks the [[epithelial sodium channel]] (ENaC) on the lumen side of the kidney [[collecting tubule]]. Other diuretics cause an increase in the sodium concentrations in the forming urine causing more sodium to enter through ENaC, chasing more potassium out of the [[principal cell]] and into the forming urine. Blocking ENaC prevents this from happening. [[Amiloride]] works in the same way. ==Side effects== Common [[adverse drug reaction|side effect]]s may include a depletion of [[sodium]], [[folic acid]] and [[calcium]], nausea, vomiting, diarrhea, headache, dizziness, fatigue, and dry mouth. Serious side effects may include heart palpitations, tingling/numbness, fever, chills, sore throat, rash, and back pain. Triamterene can also cause [[kidney stones]] through direct crystallization or by seeding [[calcium oxalate]] stones. == References == <references/> {{Antihypertensives and diuretics}} [[Category:Potassium-sparing diuretics]] {{pharma-stub}} [[de:Triamteren]] [[es:Triamtereno]] [[hr:Triamteren]] [[ja:トリアムテレン]]