Triamterene
2164556
214153316
2008-05-22T09:39:29Z
Thijs!bot
1392310
robot Adding: [[es:Triamtereno]]
{{drugbox
| IUPAC_name = 6-phenylpteridine-2,4,7-triamine
| image = Triamterene.svg
| CAS_number = 396-01-0
| ATC_prefix = C03
| ATC_suffix = DB02
| ATC_supplemental =
| PubChem = 5546
| DrugBank = APRD00079
| C = 12 | H = 11 | N = 7
| molecular_weight = 253.263 g/mol
| bioavailability =
| protein_bound = 97%
| metabolism =
| elimination_half-life =
| pregnancy_category =
| legal_status =
| routes_of_administration =
}}
'''Triamterene''' (trade name '''Dyrenium''') is a [[potassium-sparing diuretic]] used in combination with [[thiazide]] diuretics for the treatment of [[hypertension]] and [[edema]]. This medication is best avoided in patients with chronic kidney disease due to the possibility of [[hyperkalemia]]. People using this drug should use [[salt substitute]] very cautiously.<ref>LoSalt [http://www.losalt.com/docs/lo_salt_web_advice.pdf Advisory Statement] (PDF)</ref>
==Mode of action==
Triamterene directly blocks the [[epithelial sodium channel]] (ENaC) on the lumen side of the kidney [[collecting tubule]]. Other diuretics cause an increase in the sodium concentrations in the forming urine causing more sodium to enter through ENaC, chasing more potassium out of the [[principal cell]] and into the forming urine. Blocking ENaC prevents this from happening. [[Amiloride]] works in the same way.
==Side effects==
Common [[adverse drug reaction|side effect]]s may include a depletion of [[sodium]], [[folic acid]] and [[calcium]], nausea, vomiting, diarrhea, headache, dizziness, fatigue, and dry mouth. Serious side effects may include heart palpitations, tingling/numbness, fever, chills, sore throat, rash, and back pain. Triamterene can also cause [[kidney stones]] through direct crystallization or by seeding [[calcium oxalate]] stones.
== References ==
<references/>
{{Antihypertensives and diuretics}}
[[Category:Potassium-sparing diuretics]]
{{pharma-stub}}
[[de:Triamteren]]
[[es:Triamtereno]]
[[hr:Triamteren]]
[[ja:トリアムテレン]]