Vecuronium
1265737
203376981
2008-04-04T21:13:12Z
LatitudeBot
6771835
robot Modifying: [[ru:Векурония бромид]]
{{Unreferenced|date=December 2007}}
{{Drugbox|<!--Drugbox data refers to free base-->
|IUPAC_name = [(2''S'',3''S'',5''S'',8''R'',9''S'',10''S'',13''S'',14''S'',16''S'',17''S'')-<br>17-acetyloxy-10,13-dimethyl-16-(1-methyl-3,4,<br>5,6-tetrahydro-2''H''-pyridin-1-yl)-2-(1-piperidyl)-<br>2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-<br>1''H''-cyclopenta[a]phenanthren-3-yl] acetate
| image=Vecuronium structure.png
| CAS_number=50700-72-6
| ATC_prefix=M03
| ATC_suffix=AC03
| ATC_supplemental=
| PubChem=39765
| DrugBank=
| C = 34 | H = 57 | N = 2 | O = 4 | charge = +
| molecular_weight = 557.827 g/mol
| bioavailability= 100% (IV)
| metabolism = liver 30%
| elimination_half-life= 51–80 minutes (longer with renal failure)
| excretion = Fecal (40-75%) and [[kidney|renal]] (30% as unchanged drug and [[metabolite]]s)
| pregnancy_US = C
| legal_status =
| routes_of_administration= [[Intravenous therapy|Intravenous]]
}}
'''Vecuronium''' bromide (trade name '''Norcuron''') is a [[muscle relaxant]] in the category of non [[Depolarization|depolarising]] [[neuromuscular blocking agents]]. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate [[endotracheal intubation]] and to provide skeletal muscle relaxation during surgery or mechanical
ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent.
==Clinical pharmacology==
Vecuronium operates by competing for the cholinergic receptors at the motor end plate thereby exerting its muscle relaxing properties which are used adjunctively to general anesthesia. Under balanced anesthesia, the time to recovery to 25% of control (clinical duration) is
approximately 25 to 40 minutes after injection and recovery is usually 95% complete
approximately 45 to 65 minutes after injection of intubating dose. The neuromuscular
blocking action of vecuronium is slightly enhanced in the presence of potent inhalation
anesthetics. If vecuronium is first administered more than 5 minutes after the start of the
inhalation of [[enflurane]], [[isoflurane]], or [[halothane]], or when [[steady state]] has been achieved, the intubating dose of vecuronium may be decreased by approximately 15%.
Vecuronium is normally given at 0.08–0.1 mg/kg intravenously and its maintenance dose is usually between 0.02–0.03 mg/kg, but as with all other neuromuscular blocking agents, the doses need to be tailored for each individual patient.
It is an [[aminosteroid]].
==In the news==
In 2001, Japanese nurse [[Daisuke Mori]] was reported to murder 10 patients using vecuronium bromide.<ref>{{cite news|url=http://www.expressindia.com/news/ie/daily/20010111/iin11054.html|title=Japanese nurse kills 10 patients, says wanted to trouble hospital|publisher=[[The Indian Express]]|date=2001-01-10|accessdate=2008-03-22}}</ref> He was convicted of a murder and was sentenced to life imprisonment.<ref>{{cite news|url=http://www.breitbart.com/article.php?id=D8V2JI400&show_article=1|title=Top court dismisses appeal by ex-nurse over Sendai clinic murder|publisher=Breitbart.com|date=2008-02-27|accessdate=2008-03-22}}</ref>
==See also==
* [[Pancuronium]]
==References==
<span class="plainlinks"><references/></span>
{{Muscle relaxants}}
[[Category:Muscle relaxants]]
[[Category:Quaternary ammonium compounds]]
[[fr:Vécuronium]]
[[nl:Vecuronium]]
[[ro:Vecuronium]]
[[ru:Векурония бромид]]