Bromazépam 2676888 31712962 2008-07-19T19:09:33Z Naudié 364792 Ajout image {{ébauche|médecine|composé chimique}} {{Chimiebox général| nom = Bromazépam | image = Bromazepam.svg | tailleimage = 160 | commentaire = Structure chimique du bromazépam | formule = C<sub>14</sub>H<sub>10</sub>BrN<sub>3</sub>O | nom scientifique = 7-Bromo-2,3-dihydro-5-(2-pyridinyl)-<br/>1''H''-1,4-benzodiazépine-2-one | CAS = 1812-30-2 | ATC = [[ATC code N05|N05]]BA08 | apparence = }} {{Chimiebox physique}} {{Chimiebox physique masse moléculaire| 316,2}} {{Chimiebox physique fin}} {{Chimiebox pharmaco|vert}} {{Chimiebox pharmaco voie | orale}} {{Chimiebox pharmaco métabolisme | hépatique,<br/><small>métabolite actif : hydroxybromazépam}}</small> {{Chimiebox pharmaco demi-vie | 8-28 heures}} {{Chimiebox pharmaco excrétion | [[Urine|urinaire]]}} {{Chimiebox pharmaco fin}} {{Chimiebox fin}} Le '''bromazépam''' <!--(Compendium®, Creosedin®, Durazanil®, Lectopam®, Lexaurin®, Lexomil®, Lexotan®, Lexotanil®, Normoc®).{{ref|BrandNames}}--> est un [[médicament]] [[sédatif]]-[[hypnotique]] [[anxiolytique]] de la classe des [[benzodiazépine]]s. <!--Its molecular structure is composed of a [[diazepine]] connected to two [[benzene]] rings, one of which has a [[bromine]] atom attached to it.{{ref|bromazepamstructure}} It is a [[benzodiazepine|1,4-benzodiazepine]], which means that the nitrogens on the seven-sided diazepine ring are in the 1 and 4 positions. --> == Pharmacologie == Sa [[Biodisponibilité (médecine)|biodisponibilité]] est de 84 %. <!-- Bromazepam binds to the GABA receptor GABAA, causing a conformational change and increasing inhibitory effects of GABA. Other neurotransmitters are not influenced. It does not posess any antidepressant qualities. Bromazepam shares with other benzodiazepines the risk of abuse, misuse, psychological and/or physical dependence. According to many psychiatric experts Bromazepam has a greater abuse potential than other benzodiazepines because of fast resorption and rapid onset of action. Due to its relatively short halflife and duration of action (8 to 12 hours), withdrawal symptoms may be more severe and more frequently encountered than with long acting benzodiazepines. Bromazepam is reported to be metabolized by a hepatic enzyme belonging to the [[Cytochrome P450]] family of enzymes. In 2003, a team led by Dr. Oda Manami at Oita Medical University reported that [[CYP3A4]] was not the responsible enzyme, seeing as [[itraconazole]], a known inhibitor of [[CYP3A4]], did not effect its metabolism.{{ref|itraconazole}} In 1995, J. van Harten at [[Solvay Pharmaceuticals B.V.|Solvay Duphar B.V.]]'s Department of Clinical Pharmacology in [[Weesp]] reported that [[fluvoxamine]], which is a potent inhibitor of CYP1A2, a less potent [[CYP3A4]] inhibitor, and a negligible inhibitor of [[CYP2D6]], does inhibit its metabolism.{{ref|fluvoxamine}} --> == Indications == <!-- * Short-term treatment of [[insomnia]] * Short-term treatment of [[anxiety]] or [[panic-attacks]], if a benzodiazepine is required * Alleviation of the symptoms of alcohol- and opioid-withdrawal, under close clincial supervision -->'''Anxiété''' : sous toutes ses formes, en particulier anxiété névrotique, réactionnelle et manifestations somatiques associées à l'anxiété. '''Sévrage alcoolique''' : prévention et traitement du [[delirium tremens]]. == Contre-indications == ''Celles des [[benzodiazépines]]''. <!--Consult the article under [[Diazepam]].--> == Effets secondaires == Euphorie, somnolence == Posologie == <!-- Usually, 3 to 6mg at bedtime, with additional 1.5 to 3mg during the next day if needed (ambulatory patients). Emaciated patients or those with compromised cardiovascular, liver- or renal-function and the elderly should receive particular low doses. In hospitalized patients with severe agitation and/or anxiety daily doses of up to 24mg have been given and tolerated for a limited period of time. Three mg of Bromazepam are equivalent to 5mg Diazepam. --> == Spécialités à base de bromazépam == {{médicament2 | nom générique=Bromazépam |noms commerciaux=<li>Anxiocalm® (Belgique), <li>ANXYREX® (France), <li>Bromatop® (Belgique), <li>BROMAZEPAM ARROW® (France), <li>BROMAZEPAM BIOGARAN® (France), <li>Bromazepam EG® (Belgique, France), <li>BROMAZEPAM G GAM® (France), <li>BROMAZEPAM GNR® (France), <li>BROMAZEPAM IREX® (France), <li>BROMAZEPAM IVAX® (France), <li>BROMAZEPAM MERCK® (France), <li>BROMAZEPAM QUALIMED® (France), <li>Bromazepam-Ratiopharm® (Belgique, France), <li>BROMAZEPAM RPG® (France), <li>Bromazepam Teva® (Belgique, France), <li>BROMAZEPAM ZYDUS® (France), <li>Bromidem® (Belgique), <li>Docbromaze® (Belgique), <li>Kelalexan® (Belgique), <li>LEXOMIL® (France), <li>Lexotan® (Belgique), <li>Lexotanil® (Suisse), <li>QUIETILINE® (France)</li> |classe=[[Benzodiazépine]] |autres informations='''Sous classe : }} == Voir aussi == === Articles connexes === === Liens externes === * http://www.biam2.org/www/Sub2238.html == Références == <!-- # {{note|BrandNames}} [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Display&dopt=pubmed_pcsubstance_mesh&from_uid=2908134 PubChem Substance: Bromazepam] National Center of Biotechnology Information. # {{note|schedule4}} [http://www.incb.org/pdf/e/list/green.pdf List of psychotropic substances under international control] (PDF). International Narcotics Control Board. # {{note|bromazepamstructure}} [http://www.eutimia.com/psicofarmacos/ansioliticos/bromazepam.htm Bromazepam] Eutimia.com - Salud Mental. © 1999-2002. # {{note|itraconazole}} Oda M, Kotegawa T, Tsutsumi K, Ohtani Y, Kuwatani K, Nakano S. "The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healthy volunteers." ''European Journal of Clinical Pharmacology.'' 2003 Nov;59(8-9):615-9. Epub 2003 Sep 27. PMID 14517708 [http://dx.doi.org/10.1007/s00228-003-0681-4 English Fulltext (registration required)] [http://www.oita-u.ac.jp/gakui/ik-307.pdf Japanese Fulltext (PDF, no registration)] # {{note|fluvoxamine}} van Harten J. "Overview of the pharmacokinetics of fluvoxamine." ''Clinical Pharmacokinetics.'' 1995;29 Suppl 1:1-9. PMID 8846617 # {{note|bromazepam}} Ochs HR, Greenblatt DJ, Friedman H, Burstein ES, Locniskar A, Harmatz JS, Shader RI. "Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol." ''Clinical Pharmacology & Therapeutics.'' 1987 May;41(5):562-70. PMID 2882883 --> {{portail médecine}} [[Catégorie:Benzodiazépine]] [[bg:Бромазепам]] [[de:Bromazepam]] [[en:Bromazepam]] [[es:Bromazepam]] [[fi:Bromatsepaami]] [[gl:Bromazepan]] [[ht:Bromazepam]] [[it:Bromazepam]] [[ja:ブロマゼパム]] [[nl:Bromazepam]] [[pl:Bromazepam]] [[pt:Bromazepam]] [[sv:Bromazepam]]