Fluvoxamine
512631
31507287
2008-07-11T22:03:16Z
Muro Bot
403425
robot Ajoute: [[zh:氟伏沙明]]
{{ébauche|médecine}}
{{Chimiebox général|
nom = Fluvoxamine |
image = Fluvoxamine.png |
tailleimage = 160 |
commentaire = Structure de la fluvoxamine|
formule = C<sub>15</sub>H<sub>21</sub>F<sub>3</sub>N<sub>2</sub>O<sub>2</sub> |
nom scientifique = <small>2-[(5-méthoxy-1-[4-(trifluorométhyl)phényl]<br/>pentylidène)amino]oxyéthanamine</small> |
CAS = 54739-18-3 |
ATC = N06AB08 |
apparence =
}}
{{Chimiebox physique}}
{{Chimiebox physique masse moléculaire| 318.335}}
{{Chimiebox physique fin}}
{{Chimiebox pharmaco|vert}}
{{Chimiebox pharmaco voie | Oral}}
{{Chimiebox pharmaco biodisponibilité | 53%}}
{{Chimiebox pharmaco métabolisme | Hépatique}}
{{Chimiebox pharmaco demi-vie | 15.6 heures}}
{{Chimiebox pharmaco excrétion | Rénal}}
{{Chimiebox pharmaco fin}}
{{Chimiebox fin}}
La '''fluvoxamine''' est un [[médicament]] [[antidépresseur]] qui traite le [[trouble obsessionnel-compulsif]]. Son nom générique est le ''Fluvoxamine''. C'est un [[inhibiteur sélectif de la recapture de la sérotonine]].
Ses effets secondaires sont : [[constipation]], [[céphalée]]s, angoisse, irritation, problèmes sexuels, bouche sèche, des [[insomnie|problèmes de sommeil]] et un risque suicidaire en début de traitement par levée de l'inhibition psychomotrice.
Il ne faut pas consommer de [[drogues]], y compris l'alcool et le tabac, durant la prise de ce médicament et sa prescription est déconseillée aux femmes enceintes et aux jeunes de moins de dix-huit ans.
Il peut causer aussi des crises maniaques à l'origine de comportement agressif, violent. Le dosage doit être prescrit par un médecin.
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'''Fluvoxamine''' (sold under the brand-names '''Luvox'''®, '''Faverin'''® and '''Fevarin'''®) is a [[selective serotonin reuptake inhibitor]]. It is used primarily to treat [[clinical depression|depression]], [[Anxiety disorder|anxiety]] and [[Obsessive-compulsive disorder|OCD]].
Although its effects are similar to other SSRIs, it acts on the body's [[neurochemistry]] differently. For this reason, fluvoxamine can be of benefit to patients who experience unusual or limiting [[side-effect]]s from other antidepressants. Fluvoxamine also appears to cause fewer side-effects than other SSRIs, particularly in relation to loss of sex-drive.
Fluvoxamine has the shortest [[half-life]] of all the SSRIs. Its mean serum half-life is 15 hours after a single dose, and 17 to 22 hours after repeated doses.
Fluvoxamine causes many drug-[[drug interaction]]s due to inhibition of metabolism mediated by several [[cytochrome P450 oxidase]]s. Examples of substances that have higher serum levels when administered together with fluvoxamine include [[caffeine]], [[clozapine]], [[olanzapine]], [[tricyclic antidepressants]], [[diazepam]], [[alprazolam]], [[propranolol]], [[warfarin]] and [[methadone]].
==Effective dosage==
For depression and anxiety, dosage normally starts at 50 milligrams per day, rising to 100 milligrams after a few days. It may be raised after evaluation of the effects by a doctor.
Fluvoxamine is generally only effective for OCD at 150 milligrams and above, and dosages can reach 300 milligrams or more for some patients.
==Historical Relevance==
In 1999, fluvoxamine came under great public scrutiny after it was discovered that [[Eric Harris and Dylan Klebold|Eric Harris]], one of the two teenaged shooters involved in the [[Columbine High School massacre]], had been taking the drug as treatment for depression. Many immediately pointed fingers at fluvoxamine and its manufacturer Solvay Pharmaceuticals (which sells fluvoxamine under the widely known brandname Luvox), since Solvay's own clinical trials indicated the drug had the propensity to induce "mania" in 4% of the youth who took it. Solvay, while acknowledging the risks inherent in taking an SSRI medication like fluvoxamine, downplayed any role the drug may have had in the killings. The [[American Psychiatric Association]] (A.P.A.) took a similar stance; Rodrigo Munoz, M.D., President of the A.P.A., said: "Despite a decade of research, there is little valid evidence to prove a causal relationship between the use of anti-depressant medications and destructive behavior. On the other hand, there is ample evidence that undiagnosed and untreated mental illness exacts a heavy toll on those who suffer from these disorders as well as those around them." It was also pointed out by many that Luvox was often safer than the other SSRI medications available--for example, fluoxetine (Prozac) caused mania in 6% of youth tested on the drug (versus fluvoxamine's 4%). Nonetheless, the reputation of Luvox was irreparably damaged. Sales fell, and Solvay withdrew the medication from the U.S. market in 2002; the company maintains, however, that this move had nothing to do with the safety profile of the fluvoxamine, which they still sell in many countries around the world. In the United States, fluvoxamine can only be purchased generically.
The FDA currently issues the following warning with Luvox:
'''Taking antidepressants may increase suicidal thoughts and actions in about 1 out of 50 people 18 years or younger.'''[http://www.fda.gov/cder/drug/infopage/fluvoxamine/default.htm]
The UK and Health Canada have taken similar actions.
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{{médicament2 |
nom générique=Maléate de fluvoxamine
|noms commerciaux=<li>Flox-ex® (Suisse), <li>Floxyfral® (Belgique, France, Suisse), <li>Fluvoxamine EG® (Belgique, France), <li>FLUVOXAMINE MERCK® (France), <li>Fluvoxamine Sandoz® (Belgique), <li>Fluvoxamine Teva® (Belgique, France)</li> |classe=[[antidépresseur]]
|autres informations='''Sous classe : '''[[inhibiteur sélectif de la recapture de la sérotonine|ISSR]]
}}
{{Antidépresseurs}}
{{portail médecine}}
[[Catégorie:Inhibiteur sélectif de la recapture de la sérotonine]]
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[[ru:Флувоксамин]]
[[zh:氟伏沙明]]