Prazosine 523663 30853679 2008-06-21T16:06:09Z Epop 399359 +Chimiebox http://de.wikipedia.org/wiki/Prazosin {{ébauche|médecine}} {{Chimiebox général | nom = Prazosine | image = Prazosin.svg | tailleimage = | commentaire = | formule = {{fchim|C|19|H|21|N|5|O|4}} | nom scientifique = | CAS = 19216-56-9 | EINECS = | ATC = C02CA01 | apparence = }} {{Chimiebox physique}} {{Chimiebox physique masse moléculaire| 383,401 g/mol }} {{Chimiebox physique fin}} {{Chimiebox fin}} La '''prazosine''' est un [[médicament]] [[antihypertenseur]]. Il appartient à la classe des [[alpha-bloquant]]s, qui abaissent la [[tension artérielle]] par le relâchement des [[vaisseau sanguin|vaisseaux sanguins]]. La prazosine est sélective pour les récepteurs alpha1 sur les muscles lisses vasculaires. Ces récepteurs sont responsables de l'action vasoconstrictive de la [[noradrénaline]], qui a son tour élève la tension sanguine. En bloquant ces récepteurs, la prazosine abaisse la tension. <!-- '''Other features which add to the therapeutic value of Prazosin''' 1) The drug is orally active 2) Unlike other less selective alpha blockers, which often cause reflex [[tachycardia]] through the [[sympathetic]] [[baroreflex]] response that increases cardiac output, Prazosin has a minimal effect on cardiac function. 3) Prazosin is also useful in treating urinary hesitation associated with [[prostatic hypertrophy]] by blocking alpha 1 receptors which control constriction of both the [[prostate]] and [[ureters]]. Side effects of Prazosin include [[orthostatic hypotension]], [[syncope]], and nasal stuffiness. The orthostatic hypotension and syncope are associated with the body's poor ability to control blood pressure without alpha adrenergic receptors. Patients on Prazosin should be told not to stand up too quickly, since their poor baroreflex will cause them to faint as all their blood rushes to their feet. The nasal stuffines is due to the dilation of vessels in nasal mucosa, leading to congestion. One phenomenom associated with Prazosin is known as the "first dose response", in which the side effects of the drug, especially orthostatic hypotension, are especially pronounced after the first dose. --> ==Fiche== {{médicament | nom générique=Chlorhydrate de prazosine |noms commerciaux=<li>ALPRESS LP (France), <li>Minipress (Belgique, France)<BR><BR><li>non commercialisé en Suisse<BR><BR><li>dernière mise à jour : 13/12/2005</li> |classe=[[Antihypertenseur]] |autres informations='''Sous classe :''' [[Alpha-bloquant]] }} {{portail médecine}} [[Catégorie:Alpha-bloquant]] [[de:Prazosin]] [[en:Prazosin]] [[hr:Prazosin]] [[ja:プラゾシン]]